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RB1 Antibody

CAT: 0223-62-205Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-62-205Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The retinoblastoma protein is a tumor suppressor protein that is dysfunctional in many types of cancer.[1] One highly studied function of pRb is to prevent excessive cell growth by inhibiting cell cycle progression until a cell is ready to divide. pRb belongs to the pocket protein family, whose members have a pocket for the functional binding of other proteins.[2][3] Should an oncogenic protein, such as those produced by cells infected by high-risk types of human papillomaviruses, bind and inactivate pRb, this can lead to cancer. Retinoblastoma (RB) is an embryonic malignant neoplasm of retinal origin. It almost always presents in early childhood and is often bilateral.
NCBI Gene ID
5925
Swiss Prot
P06400
Accession Number
P06400
Host
Rabbit
Reactivity
Human
Immunogen
This RB1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 586-615 amino acids from human RB1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Cell Cycle
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
106 kDa
Fragment
Rabbit Ig
Symbol
RB1
NCBI Official Name
Retinoblastoma-associated protein
NCBI Organism
Homo sapiens
Background Reference 01
Dasgupta, P., et al., Mol. Cell. Biol. 24 (21) :9527-9541 (2004) .
Background Reference 02
Cui, X., et al., Hum. Pathol. 35 (10) :1189-1195 (2004) .
Background Reference 03
Borah, S., et al., J. Virol. 78 (19) :10336-10347 (2004) .
Background Reference 04
Dasgupta, P., et al., J. Biol. Chem. 279 (37) :38762-38769 (2004) .
Other Product Names
Retinoblastoma-associated protein, p105-Rb, pRb, Rb, pp110, RB1
Tested Applications
WB, IHC-P, IF
Protein ID
132164
Physical Properties
Liquid

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