Retinoblastoma (phospho Ser608) Antibody

• Background:

  Retinoblastoma (RB) is an embryonic malignant neoplasm of retinal origin. It almost always presents in early childhood and is often bilateral. Spontaneous regression ('cure') occurs in some cases.

• NCBI Gene ID:

  5925

• Swiss Prot:

  P06400

• Accession Number:

  NP_000312.2

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Immunogen:

  Retinoblastoma (phospho Ser608) antibody was raised against a peptide sequence around phosphorylation site of Serine 608 (Y-L-S (p) -P-V) derived from Human Retinoblastoma.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Phospho-Specific

• Purification:

  Antibodies were purified by affinity-chromatography using epitope-specific peptide.

• Concentration:

  1 mg/mL

• Buffer:

  Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

• Modification:

  Phospho-Specific

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store antibody at -20˚ C for up to one year.

• Calculated Molecular Weight:

  110 kDa

• Fragment:

  IgG

• Specificity:

  The antibody detects endogenous levels of Retinoblastoma only when phosphorylated at serine 608.

• Applications Notes:

  Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100

• Symbol:

  RB1

• NCBI Official Name:

  Retinoblastoma 1

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Lee W.-H., Nature 329:642-645 (1987) .

• Background Reference 02:

  Lee W.-H., Science 235:1394-1399 (1987) .

• Background Reference 03:

  Friend S.H., Proc. Natl. Acad. Sci. U.S.A. 84:9059-9063 (1987) .

• Other Product Names:

  P105-RB, PP105, PP110, RB1

• Tested Applications:

  WB, IHC

• Protein ID:

  108773787

• Physical Properties:

  Liquid