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MDM4 Antibody

CAT: 0223-31-051Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0223-31-051Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
MDM4 inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. inhibits degradation of MDM2. It can reverse MDM2-targeted degradation of p53 while maintaining suppression of p53 transactivation and apoptotic functions.The human MDM4 gene, which plays a role in apoptosis, encodes a 490-amino acid protein containing a RING finger domain and a putative nuclear localization signal. The MDM4 putative nuclear localization signal, which all Mdm proteins contain, is located in the C-terminal region of the protein. The mRNA is expressed at a high level in thymus and at lower levels in all other tissues tested. MDM4 protein produced by in vitro translation interacts with p53 via a binding domain located in the N-terminal region of the MDM4 protein. MDM4 shows significant structural similarity to p53-binding protein MDM2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
NCBI Gene ID
4194
Swiss Prot
O15151
Accession Number
NP_002384
Host
Rabbit
Reactivity
Human
Immunogen
Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human MDM4.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cell Cycle, Cancer, Apoptosis
Purification
Antibody is purified by protein A chromatography method.
Concentration
Batch dependent
Buffer
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
For short periods of storage (days) store at 4˚ C. For longer periods of storage, store MDM4 antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.
Calculated Molecular Weight
55 kDa
Applications Notes
MDM4 antibody can be used for detection of MDM4 by ELISA at 1:62500. MDM4 antibody can be used for detection of MDM4 by western blot at 2.5 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
Symbol
MDM4
NCBI Official Name
Mdm4 p53 binding protein homolog (mouse)
NCBI Organism
Homo sapiens
Background Reference 01
Gilkes, D.M., (2008) Mol. Cell. Biol. 28 (6), 1999-2010.
Other Product Names
MDM4, DKFZp781B1423, MDMX, MGC132766, MRP1, HDMX
Tested Applications
ELISA, WB
Protein ID
88702791
Physical Properties
Liquid

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