BCL11A Antibody

BCL11A Is a C2H2 type zinc-finger protein by its similarity to the mouse Bcl11a/Evi9 protein. The corresponding mouse gene is a common site of retroviral integration in myeloid leukemia, and may function as a leukemia disease gene, in part, through its interaction with BCL6. During hematopoietic cell differentiation, this gene is down-regulated. It is possibly involved in lymphoma pathogenesis since translocations associated with B-cell malignancies also deregulates its expression.This gene encodes a C2H2 type zinc-finger protein by its similarity to the mouse Bcl11a/Evi9 protein. The corresponding mouse gene is a common site of retroviral integration in myeloid leukemia, and may function as a leukemia disease gene, in part, through its interaction with BCL6. During hematopoietic cell differentiation, this gene is down-regulated. It is possibly involved in lymphoma pathogenesis since translocations associated with B-cell malignancies also deregulates its expression. Multiple transcript variants encoding several different isoforms have been found for this gene.

53335

Q9H165

NP_075044

Human, Mouse, Rat

Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human BCL11A.

Unconjugated

Primary Antibodies

Transcription, Cancer

Antibody is purified by peptide affinity chromatography method.

Cat. No. XBL-10407 - Fetal Heart Tissue Lysate

Batch dependent

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

None

Blue Ice

For short periods of storage (days) store at 4˚ C. For longer periods of storage, store BCL11A antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.

91 kDa

BCL11A antibody can be used for detection of BCL11A by ELISA at 1:1562500. BCL11A antibody can be used for detection of BCL11A by western blot at 1 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

BCL11A

B-cell CLL/lymphoma 11A (zinc finger protein)

Homo sapiens

Uda, M., (2008) Proc. Natl. Acad. Sci. U.S.A. 105 (5), 1620-1625.

BCL11A, BCL11A-L, BCL11A-S, BCL11A-XL, CTIP1, EVI9, FLJ10173, FLJ34997, HBFQTL5, KIAA1809, ZNF856, BCL11a-M

ELISA, WB

20336305