BCL10 Antibody [4F8E8H8]

• Background:

  B-cell CLL/lymphoma 10, also known as CLAP, Me10, CIPER, c-E10, CARMEN. Entrez Protein NP_003912. It is a protein containing a caspase recruitment domain (CARD) . It plays an important role in apoptosis and activating NF-κ B. The research suggested that it interacted with other CARD domain containing proteins including CARD9, 10, 11 and 14, which were thought to function as upstream regulators in NF-κ B signaling. Bcl-10 is found to form a complex with MALT1 which encoded by another gene known to be translocated in MALT lymphoma. MALT1 and Bcl-10 are thought to synergize in the activation of NF-κ B, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy.

• NCBI Gene ID:

  8915

• Swiss Prot:

  O95999

• Accession Number:

  O95999

• Host:

  Mouse

• Reactivity:

  Human

• Immunogen:

  Ni-NTA purified recombinant human BCL-10 expressed in E. Coli strain BL21 (DE3) .

• Clonality:

  Monoclonal

• Clone:

  4F8E8H8

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Signal Transduction, Apoptosis

• Purification:

  Antibody is purified by protein A affinity chromatography.

• Concentration:

  Batch dependent

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  BCL-10 monoclonal antibody can be stored at -20˚ C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Fragment:

  IgG1

• Symbol:

  BCL10

• NCBI Official Name:

  B-cell CLL/lymphoma 10

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Willis, T.G., et al. (1999) Cell. 96, 35-45.

• Background Reference 02:

  Lucas, P.C., et al. (2001) J. Biol.Chem. 276, 19012-19019.

• Background Reference 03:

  Wang, L., et al. (2001) J. Biol.Chem. 276, 21405-21409

• Other Product Names:

  CIPER, CLAP, CARD-containing molecule enhancing NF-kappa-B, Bcl-10, mE10, CIPER, c-E10, CARMEN

• Tested Applications:

  ELISA, WB, IHC

• Protein ID:

  20454813

• Physical Properties:

  Liquid