BCL2A1 Antibody

• Background:

  BCL2A1s a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators that are involved in a wide variety of cellular activities such as embryonic development, homeostasis and tumorigenesis. The protein encoded by this gene is able to reduce the release of pro-apoptotic cytochrome c from mitochondria and block caspase activation. This gene is a direct transcription target of NF-kappa B in response to inflammatory mediators, and has been shown to be up-regulated by different extracellular signals, such as granulocyte-macrophage colony-stimulating factor (GM-CSF), CD40, phorbol ester and inflammatory cytokine TNF and IL-1, which suggests a cytoprotective function that is essential for lymphocyte activation as well as cell survival.

• NCBI Gene ID:

  597

• Swiss Prot:

  Q16548

• Accession Number:

  NP_004040

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human BCL2A1.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Transcription, Cancer

• Purification:

  Antibody is purified by peptide affinity chromatography method.

• Positive Control:

  Cat. No. 1205 - Jurkat Cell Lysate

• Concentration:

  Batch dependent

• Buffer:

  Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  For short periods of storage (days) store at 4˚ C. For longer periods of storage, store BCL2A1 antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.

• Calculated Molecular Weight:

  20 kDa

• Applications Notes:

  BCL2A1 antibody can be used for detection of BCL2A1 by ELISA at 1:12500. BCL2A1 antibody can be used for detection of BCL2A1 by western blot at 1 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

• Symbol:

  BCL2A1

• NCBI Official Name:

  BCL2-related protein A1

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Kunter, U., et al., (2005) Kidney Int. 68 (4), 1520-1532.

• Other Product Names:

  BCL2A1, GRS, BFL1, ACC-1, ACC-2, HBPA1, BCL2L5

• Tested Applications:

  ELISA, WB

• Protein ID:

  4757840

• Physical Properties:

  Liquid