BCL10 Antibody

• Background:

  This gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The protein encoded by this gene contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy. Alternative splicing results in multiple transcript variants.

• NCBI Gene ID:

  8915

• Swiss Prot:

  O95999

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Immunogen:

  A synthetic peptide of human BCL10

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Apoptosis, Cancer, Cell Cycle, Immunology, Signal Transduction

• Purification:

  Affinity purification

• Positive Control:

  Mouse ovary

• Concentration:

  Batch dependent

• Buffer:

  PBS with 0.02% sodium azide, pH7.3.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C (regular) or -20˚ C (long term) . Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  Observed: 32kDa

• Fragment:

  IgG

• Symbol:

  BCL10

• NCBI Official Name:

  B-cell CLL/lymphoma 10

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  Bcl-10 Antibody: CLAP, mE10, CIPER, c-E10, CARMEN, CLAP, CARD-containing molecule enhancing NF-kappa-B, Bcl-10

• Tested Applications:

  WB, IHC, IF, Flow

• Physical Properties:

  Liquid