MAP3K3 Antibody

CAT: 0223-16-404Size: 100 µLDry Ice: NoHazardous: No
CAT#:0223-16-404Size:100 µL
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Background
This gene product is a 626-amino acid polypeptide that is 96.5% identical to mouse Mekk3. Its catalytic domain is closely related to those of several other kinases, including mouse Mekk2, tobacco NPK, and yeast Ste11. Northern blot analysis revealed a 4.6-kb transcript that appears to be ubiquitously expressed. This protein directly regulates the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by activating SEK and MEK1/2 respectively; it does not regulate the p38 pathway. In cotransfection assays, it enhanced transcription from a nuclear factor kappa-B (NFKB) -dependent reporter gene, consistent with a role in the SAPK pathway. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
NCBI Gene ID
4215
Swiss Prot
Q99759
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-220 of human MAP3K3 (NP_976226.1) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cell Cycle, Immunology, Innate Immunity, Signal Transduction
Purification
Affinity purification
Positive Control
K-562
Concentration
Batch dependent
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at -20˚ C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
Observed: 71kDa
Fragment
IgG
Symbol
MAP3K3
Positive Control 2
Mouse brain
Positive Control 3
Mouse liver
Positive Control 4
Rat pancreas
NCBI Official Name
Mitogen-activated protein kinase kinase kinase 3
NCBI Organism
Homo sapiens
Other Product Names
MAP3K3, MAPK/ERK kinase kinase 3, MAPKKK3, MEK kinase 3, MEKK3, MAP/ERK kinase kinase 3, MEKK 3
Tested Applications
WB, IHC
Physical Properties
Liquid

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