MAP3K3 Antibody

• Background :

  This gene product is a 626-amino acid polypeptide that is 96.5% identical to mouse Mekk3. Its catalytic domain is closely related to those of several other kinases, including mouse Mekk2, tobacco NPK, and yeast Ste11. Northern blot analysis revealed a 4.6-kb transcript that appears to be ubiquitously expressed. This protein directly regulates the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by activating SEK and MEK1/2 respectively; it does not regulate the p38 pathway. In cotransfection assays, it enhanced transcription from a nuclear factor kappa-B (NFKB) -dependent reporter gene, consistent with a role in the SAPK pathway. Alternatively spliced transcript variants encoding distinct isoforms have been observed.

• NCBI Gene ID :

  4215

• Swiss Prot :

  Q99759

• Host :

  Rabbit

• Reactivity :

  Human, Mouse, Rat

• Immunogen :

  Recombinant fusion protein containing a sequence corresponding to amino acids 1-220 of human MAP3K3 (NP_976226.1) .

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Cell Cycle, Immunology, Innate Immunity, Signal Transduction

• Purification :

  Affinity purification

• Positive Control :

  K-562

• Concentration :

  Batch dependent

• Buffer :

  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  Store at -20˚ C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight :

  Observed: 71kDa

• Fragment :

  IgG

• Symbol :

  MAP3K3

• Positive Control 2 :

  Mouse brain

• Positive Control 3 :

  Mouse liver

• Positive Control 4 :

  Rat pancreas

• NCBI Official Name :

  Mitogen-activated protein kinase kinase kinase 3

• NCBI Organism :

  Homo sapiens

• Other Product Names :

  MAP3K3, MAPK/ERK kinase kinase 3, MAPKKK3, MEK kinase 3, MEKK3, MAP/ERK kinase kinase 3, MEKK 3

• Tested Applications :

  WB, IHC

• Physical Properties :

  Liquid