MAP3K8 Antibody

CAT: 0223-27-310Size: 100 µLDry Ice: NoHazardous: No
CAT#:0223-27-310Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
MAP3K8 is a member of the serine/threonine protein kinase family. This kinase can activate both the MAP kinase and JNK kinase pathways. This kinase was shown to activate IkappaB kinases, and thus induce the nuclear production of NF-kappaB. This kinase was also found to promote the production of TNF-alpha and IL-2 during T lymphocyte activation. Studies of a similar gene in rat suggested the direct involvement of this kinase in the proteolysis of NF-kappaB1, p105 (NFKB1) . This gene may also utilize a downstream in-frame translation start codon, and thus produce an isoform containing a shorter N-terminus. The shorter isoform has been shown to display weaker transforming activity.
NCBI Gene ID
1326
Swiss Prot
P41279
Accession Number
NP_005195
Host
Rabbit
Reactivity
Human, Rat, Dog
Immunogen
Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human MAP3K8.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Signal Transduction
Purification
Antibody is purified by protein A chromatography method.
Positive Control
Cat. No. 1205 - Jurkat Cell Lysate
Concentration
Batch dependent
Buffer
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
For short periods of storage (days) store at 4˚ C. For longer periods of storage, store MAP3K8 antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.
Calculated Molecular Weight
53 kDa
Applications Notes
MAP3K8 antibody can be used for detection of MAP3K8 by ELISA at 1:1562500. MAP3K8 antibody can be used for detection of MAP3K8 by western blot at 2.5 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
Symbol
MAP3K8
NCBI Official Name
Mitogen-activated protein kinase kinase kinase 8
NCBI Organism
Homo sapiens
Background Reference 01
Jia, Y., et al., (2005) Arch. Biochem. Biophys. 441 (1), 64-74.
Other Product Names
MAP3K8, COT, EST, ESTF, TPL2, MEKK8, Tpl-2, c-COT
Tested Applications
ELISA, WB
Protein ID
22035598
Physical Properties
Liquid

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