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MAP3K8 Antibody

CAT: 0223-16-144Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0223-16-144Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
This gene is an oncogene that encodes a member of the serine/threonine protein kinase family. The encoded protein localizes to the cytoplasm and can activate both the MAP kinase and JNK kinase pathways. This protein was shown to activate IkappaB kinases, and thus induce the nuclear production of NF-kappaB. This protein was also found to promote the production of TNF-alpha and IL-2 during T lymphocyte activation. This gene may also utilize a downstream in-frame translation start codon, and thus produce an isoform containing a shorter N-terminus. The shorter isoform has been shown to display weaker transforming activity. Alternate splicing results in multiple transcript variants that encode the same protein.
NCBI Gene ID
1326
Swiss Prot
P41279
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human MAP3K8 (NP_005195.2) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Cell Cycle, Immunology, Signal Transduction
Purification
Affinity purification
Concentration
Batch dependent
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at -20˚ C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
Observed: 58kDa
Fragment
IgG
Applications Notes
WB: 1:500 - 1:2000
Symbol
MAP3K8
NCBI Official Name
Mitogen-activated protein kinase kinase kinase 8
NCBI Organism
Homo sapiens
Other Product Names
MAP3K8, COT, EST, ESTF, TPL2, MEKK8, Tpl-2, c-COT
Tested Applications
WB
Physical Properties
Liquid

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