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MAP2K3 Antibody

CAT: 0223-23-127Size: 100 µLDry Ice: NoHazardous: No
CAT#:0223-23-127Size:100 µL
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Background
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells. The inhibition of this kinase is involved in the pathogenesis of Yersina pseudotuberculosis. Multiple alternatively spliced transcript variants that encode distinct isoforms have been reported for this gene.
NCBI Gene ID
5606
Swiss Prot
P46734
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-170 of human MAP2K3 (NP_659731.1) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Cell Cycle, Immunology, Innate Immunity, Neuroscience, Signal Transduction
Purification
Affinity purification
Positive Control
Mouse heart
Concentration
Batch dependent
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at -20˚ C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
Observed: 39kDa
Fragment
IgG
Symbol
MAP2K3
Positive Control 2
Mouse skeletal muscle
NCBI Official Name
Mitogen-activated protein kinase kinase 3
NCBI Organism
Homo sapiens
Other Product Names
MAP2K3, MAPKK 3, MAPKK3, PRKMK3, SAPK kinase 2, SAPKK-2, SAPKK2, SKK2, MAP kinase kinase 3, MEK 3, MEK3, MKK3, MAPK/ERK kinase 3
Tested Applications
WB, IF
Physical Properties
Liquid

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MBS7124086-01MAP2K3 Antibody

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