PARP1 Antibody, KO Validated

• Background:

  This gene encodes a chromatin-associated enzyme, poly (ADP-ribosyl) transferase, which modifies various nuclear proteins by poly (ADP-ribosyl) ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes.

• NCBI Gene ID:

  142

• Swiss Prot:

  P09874

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Recombinant fusion protein containing a sequence corresponding to amino acids 81-390 of human PARP1 (NP_001609.2) .

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Validation:

  Antibody is Knockout validated.

• Field of Research:

  Cell Cycle, Immunology, Signal Transduction

• Purification:

  Affinity purification

• Positive Control:

  Jurkat

• Concentration:

  Batch dependent

• Buffer:

  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at -20˚ C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  Observed: 100kDa, 110kDa, 125kDa

• Fragment:

  IgG

• Symbol:

  PARP1

• Positive Control 2:

  HeLa

• Positive Control 3:

  RAW264.7

• Positive Control 4:

  C6

• Positive Control 5:

  Mouse testis

• Positive Control 6:

  Mouse brain

• NCBI Official Name:

  Poly (ADP-ribose) polymerase 1

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  KIF3B, PARP, PPOL, ADPRT, ARTD1, ADPRT1, PARP-1, ADPRT 1, pADPRT-1

• Tested Applications:

  WB, IHC, IF, IP, CHIP

• Physical Properties:

  Liquid