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PARP1 Antibody

CAT: 0223-56-978Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-56-978Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
This gene encodes a chromatin-associated enzyme, poly (ADP-ribosyl) transferase, which modifies various nuclear proteins by poly (ADP-ribosyl) ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes.
NCBI Gene ID
142
Swiss Prot
P09874
Accession Number
P09874
Host
Rabbit
Reactivity
Human
Immunogen
This PARP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 58-87 amino acids from the N-terminal region of human PARP1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cell Cycle, Obesity
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Hamster, Mouse, Rat
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
113 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
PARP1
NCBI Official Name
Poly [ADP-ribose] polymerase 1
NCBI Organism
Homo sapiens
Background Reference 01
Majewski, P.M., et al. J. Biol. Chem. 285 (45) :34828-34838 (2010)
Background Reference 02
Kim, M., et al. Cancer Sci. 101 (11) :2436-2442 (2010)
Background Reference 03
Dong, Y., et al. Cancer Res. 70 (20) :8088-8096 (2010)
Background Reference 04
Krishnakumar, R., et al. Mol. Cell 39 (5) :736-749 (2010)
Other Product Names
Poly [ADP-ribose] polymerase 1, PARP-1, ADP-ribosyltransferase diphtheria toxin-like 1, ARTD1, NAD (+) ADP-ribosyltransferase 1, ADPRT 1, Poly[ADP-ribose] synthase 1, PARP1, ADPRT, PPOL
Tested Applications
WB
Protein ID
130781
Physical Properties
Liquid

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