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PARP1 Antibody

CAT: 0223-61-315Size: 200 µLDry Ice: NoHazardous: No
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CAT#:0223-61-315Size:200 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Involved in the base excision repair (BER) pathway, by catalyzing the poly (ADP-ribosyl) ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. Mediates the poly (ADP- ribosyl) ation of APLF and CHFR. Positively regulates the transcription of MTUS1 and negatively regulates the transcription of MTUS2/TIP150. With EEF1A1 and TXK, forms a complex that acts as a T-helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production. Required for PARP9 and DTX3L recruitment to DNA damage sites. PARP1-dependent PARP9-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites.
NCBI Gene ID
142
Swiss Prot
P09874
Accession Number
P09874
Host
Rabbit
Reactivity
Human
Immunogen
This antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 191-225 amino acids from human.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cell Cycle, Obesity
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
113 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:500
Symbol
PARP1
NCBI Official Name
Poly [ADP-ribose] polymerase 1
NCBI Organism
Homo sapiens
Background Reference 01
Uchida K., et al.Biochem. Biophys. Res. Commun. 148:617-622 (1987) .
Background Reference 02
Kurosaki T., et al.J. Biol. Chem. 262:15990-15997 (1987) .
Background Reference 03
Cherney B.W., et al.Proc. Natl. Acad. Sci. U.S.A. 84:8370-8374 (1987) .
Background Reference 04
Auer B., et al.DNA 8:575-580 (1989) .
Other Product Names
Poly [ADP-ribose] polymerase 1, PARP-1, 2.4.2.30, ADP-ribosyltransferase diphtheria toxin-like 1, ARTD1, NAD (+) ADP-ribosyltransferase 1, ADPRT 1, Poly[ADP-ribose] synthase 1, PARP1, ADPRT, PPOL
Tested Applications
WB
Protein ID
130781
Physical Properties
Liquid

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