TNF-α agonistic 1

• UNSPSC Description:

  TNF-α agonistic 1 (compound 22a) can repolarize tumor-associated macrophages (TAMs) in the tumor microenvironment (TME) from the M2 phenotype to the M1 anti-tumor phenotype[1].

• Target Antigen:

  Others

• Type:

  Reference compound

• Related Pathways:

  Others

• Applications:

  Cancer-programmed cell death

• Field of Research:

  cancer

• Assay Protocol:

  https://www.medchemexpress.com/tnf-α-agonistic-1.html

• Smiles:

  O=C(NC1CC2=C(CC1)NC3=CC(C4=CN(C)N=C4)=CC=C23)NC5=CC=C(C(C(F)(F)F)=C5)Cl

• Molecular Weight:

  487.90

• References & Citations:

  [1]Pei H, et al. Discovery of potent ureido tetrahydrocarbazole derivatives for cancer treatments through targeting tumor-associated macrophages. Eur J Med Chem. 2019 Dec 1;183:111741.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2379727-88-3