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TNF-α-IN-19

CAT: 0804-HY-114573-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-114573-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
TNF-α-IN-19 is an inhibitor of TNFα that can block the interaction between TNFαRI, TRADD, and RIP1, the EC50 values for TNFα, IL-1β, and IL-1β/TNFα are 2.451, 3.792 and 1.54 μM, respectively. TNF-α-IN-19 only inhibits the degradation of IκBα when cells are stimulated by TNFα and not by IL-1β[1].
CAS Number
338773-13-0
UNSPSC
12352005
Target
IKK; Interleukin Related; RIP kinase; TNF Receptor
Type
Reference compound
Related Pathways
Apoptosis; Immunology/Inflammation; NF-κB
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/tnf-α-in-19.html
Smiles
ClC1=CC=C(C2=NN=C3N2C4=C(N=C3C(F)(F)F)C=CC=C4)C=C1
Molecular Formula
C16H8ClF3N4
Molecular Weight
348.71
References & Citations
[1]Tarikere L. Gururaja, et al. A Class of SmallMolecules thatInhibit TNFa-Induced Survival and Death Pathways via Prevention of Interactions between TNFaRI, TRADD, and RIP1. Chemistry & Biology. 2007; 14 (10), 1105–1118.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
IL-1

Chemical Information

1-(4-Chlorophenyl)-4-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]quinoxaline
CAS Number338773-13-0
PubChem CID1470913
IUPAC Name1-(4-chlorophenyl)-4-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]quinoxaline
Molecular FormulaC16H8ClF3N4
Molecular Weight348.71
XLogP4.7
Topological Polar Surface Area43.1
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count6
Rotatable Bond Count1
Heavy Atom Count24
Formal Charge0
Complexity455
SMILES
C1=CC=C2C(=C1)N=C(C3=NN=C(N23)C4=CC=C(C=C4)Cl)C(F)(F)F
InChI
InChI=1S/C16H8ClF3N4/c17-10-7-5-9(6-8-10)14-22-23-15-13(16(18,19)20)21-11-3-1-2-4-12(11)24(14)15/h1-8H
InChIKey
PEOTYDSXVIEYAM-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 1-(4-Chlorophenyl)-4-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]quinoxaline
CAS: 338773-13-0
CID: 1470913
Formula: C16H8ClF3N4
MW: 348.71
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight348.71
XLogP34.7
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count6
Rotatable Bond Count1
Exact Mass348.0389585
Monoisotopic Mass348.0389585
Topological Polar Surface Area43.1 Ų
Heavy Atom Count24
Formal Charge0
Complexity455
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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sc-12744 AF790TNFα (TN3-19.12) Alexa Fluor® 790
sc-12744 AF594TNFα (TN3-19.12) Alexa Fluor® 594
sc-12744 AF488TNFα (TN3-19.12) Alexa Fluor® 488
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