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Methotrexate-alpha-alanine

CAT: 0804-HY-165164Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-165164Size:1 Each
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Description
Methotrexate-alpha-alanine is a prodrug for activation by enzyme-monoclonal antibody conjugates of Methotrexate. Methotrexate-alpha-alanine shows cytotoxicity[1][2].
CAS Number
116819-28-4
UNSPSC
12352005
Target
Drug Intermediate
Type
Reference compound
Related Pathways
Others
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/methotrexate-alpha-alanine.html
Smiles
NC1=NC(N)=NC2=C1N=C(CN(C3=CC=C(C=C3)C(N[C@@H](CCC(O)=O)C(N[C@@H](C)C(O)=O)=O)=O)C)C=N2
Molecular Formula
C23H27N9O6
Molecular Weight
525.52
References & Citations
[1]Haenseler E, et al. Activation of methotrexate-alpha-alanine by carboxypeptidase A-monoclonal antibody conjugate. Biochemistry. 1992 Jan 28;31 (3) :891-7.|[2]Huennekens FM. Development of methotrexate alpha-peptides as prodrugs for activation by enzyme-monoclonal antibody conjugates. Adv Enzyme Regul. 1997;37:77-92.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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