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Methotrexate (monohydrate)

CAT: 0804-HY-14519DSize: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-14519DSize:1 Each
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Description
Methotrexate (Amethopterin) monohydrate, an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis. Methotrexate monohydrate, also an immunosuppressant and antineoplastic agent, is used for the research of rheumatoid arthritis and a number of different cancers (such as acute lymphoblastic leukemia) [1][2][3].
CAS Number
[6745-93-3]
Product Name Alternative
Amethopterin (monohydrate) ; CL14377 (monohydrate) ; WR19039 (monohydrate)
UNSPSC
12352203
Target
ADC Payload; Antifolate; Apoptosis; Bacterial; DNA/RNA Synthesis
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related; Anti-infection; Apoptosis; Cell Cycle/DNA Damage
Applications
COVID-19-anti-virus
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/methotrexate-monohydrate.html
Solubility
10 mM in DMSO
Smiles
NC1=NC(N)=C2C(N=CC(CN(C)C3=CC=C(C(N[C@@H](CCC(O)=O)C(O)=O)=O)C=C3)=N2)=N1.O
Molecular Formula
C20H24N8O6
Molecular Weight
472.45
References & Citations
[1]Tian H, et al. Understanding the mechanisms of action of methotrexate: implications for the treatment of rheumatoid arthritis. Bull NYU Hosp Jt Dis. 2007;65 (3) :168-73.|[2]Swierkot J, et al. Methotrexate in rheumatoid arthritis. Pharmacol Rep. 2006 Jul-Aug;58 (4) :473-92.|[3]Ehab Tousson, et al. The Effect of L-carnitine on Amethopterin-induced Toxicity in Rat Large Intestine.|[4]Banji D, et al. Evaluation of the concomitant use of methotrexate and curcumin on Freund's complete adjuvant-induced arthritis and hematological indices in rats. Indian J Pharmacol. 2011;43 (5) :546-550.
Shipping Conditions
Room temperature
Scientific Category
ADC Related
Clinical Information
Launched
Isoform
Traditional Cytotoxic Agents

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