(±) -Methotrexate

CAT: 0804-HY-121151Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-121151Size:1 Each
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Description
(±) -Methotrexate ((±) -Amethopterin) is a racemate of Methotrexate (HY-14519) . Methotrexate, an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of Folic acid into Tetrahydrofolate, and inhibiting DNA synthesis[1].
CAS Number
[60388-53-6]
Product Name Alternative
(±) -Amethopterin; (±) -CL14377; (±) -WR19039
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
Antifolate
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/racemic-methotrexate.html
Smiles
O=C(C(CCC(O)=O)NC(C1=CC=C(C=C1)N(C)CC2=NC3=C(N=C(N=C3N=C2)N)N)=O)O
Molecular Formula
C20H22N8O5
Molecular Weight
454.44
Precautions
P261-P280-P302+P352
References & Citations
[1]Tian H, et al. Understanding the mechanisms of action of methotrexate: implications for the treatment of rheumatoid arthritis. Bull NYU Hosp Jt Dis. 2007;65 (3) :168-73.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Launched

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