(±) -Methotrexate

• Description:

  (±) -Methotrexate ((±) -Amethopterin) is a racemate of Methotrexate (HY-14519) . Methotrexate, an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of Folic acid into Tetrahydrofolate, and inhibiting DNA synthesis[1].

• Product Name Alternative:

  (±) -Amethopterin; (±) -CL14377; (±) -WR19039

• UNSPSC:

  12352005

• Hazard Statement:

  H302-H315-H319-H335

• Target:

  Antifolate

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage

• Field of Research:

  Others

• Assay Protocol:

  https://www.medchemexpress.com/racemic-methotrexate.html

• Smiles:

  O=C (C (CCC (O) =O) NC (C1=CC=C (C=C1) N (C) CC2=NC3=C (N=C (N=C3N=C2) N) N) =O) O

• Molecular Formula:

  C20H22N8O5

• Molecular Weight:

  454.44

• Precautions:

  P261-P280-P302+P352

• References & Citations:

  [1]Tian H, et al. Understanding the mechanisms of action of methotrexate: implications for the treatment of rheumatoid arthritis. Bull NYU Hosp Jt Dis. 2007;65 (3) :168-73.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  Launched

• CAS Number:

  60388-53-6