(±) -Methotrexate

• Description :

  (±) -Methotrexate ((±) -Amethopterin) is a racemate of Methotrexate (HY-14519) . Methotrexate, an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of Folic acid into Tetrahydrofolate, and inhibiting DNA synthesis[1].

• Product Name Alternative :

  (±) -Amethopterin; (±) -CL14377; (±) -WR19039

• UNSPSC :

  12352005

• Hazard Statement :

  H302-H315-H319-H335

• Target :

  Antifolate

• Type :

  Reference compound

• Related Pathways :

  Cell Cycle/DNA Damage

• Field of Research :

  Others

• Assay Protocol :

  https://www.medchemexpress.com/racemic-methotrexate.html

• Smiles :

  O=C(C(CCC(O)=O)NC(C1=CC=C(C=C1)N(C)CC2=NC3=C(N=C(N=C3N=C2)N)N)=O)O

• Molecular Formula :

  C20H22N8O5

• Molecular Weight :

  454.44

• Precautions :

  P261-P280-P302+P352

• References & Citations :

  [1]Tian H, et al. Understanding the mechanisms of action of methotrexate: implications for the treatment of rheumatoid arthritis. Bull NYU Hosp Jt Dis. 2007;65 (3) :168-73.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  Launched

• CAS Number :

  [60388-53-6]