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Methotrexate metabolite

CAT: 0804-HY-108251-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-108251-01Size:5 mg
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Description
Methotrexate metabolite (DAMPA) is an active metabolite of Methotrexate. Methotrexate is a Folic acid antagonist, widely used as an immunosuppressant. Methotrexate metabolite is an antimalarial agent that inhibits parasite growth under physiological folic acid conditions, with IC50 values of 446 nM and 812 nM against folic acid-sensitive strains and highly resistant strains, respectively. Methotrexate metabolite exhibits pharmacokinetic characteristics of rapid clearance and extensive metabolism, with a mean clearance rate of 1.9 l/kg/h and a mean terminal half-life of 51 minutes. Methotrexate metabolite is promising for research in the field of inflammation[2][3].
CAS Number
19741-14-1
Product Name Alternative
DAMPA
UNSPSC
12352005
Hazard Statement
H301, H315, H319, H341, H360
Target
Antifolate; Dihydrofolate reductase (DHFR) ; Drug Metabolite; Parasite
Type
Reference compound
Related Pathways
Anti-infection; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease
Applications
COVID-19-anti-virus
Field of Research
Infection; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/methotrexate-metabolite.html
Purity
98.44
Solubility
DMSO : 5 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(O)C1=CC=C(N(CC2=NC3=C(N)N=C(N)N=C3N=C2)C)C=C1
Molecular Formula
C15H15N7O2
Molecular Weight
325.33
Precautions
H301, H315, H319, H341, H360
References & Citations
[1]Schofield RC, et al. Development and validation of a turbulent flow chromatography and tandem mass spectrometry method for the quantitation of methotrexate and its metabolites 7-hydroxy methotrexate and DAMPA in serum. J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Oct 1;1002:169-75.|[2]Nduati E, et al., 2,4-diaminopteridine-based compounds as precursors for de novo synthesis of antifolates: a novel class of antimalarials. Antimicrob Agents Chemother. 2005 Sep;49 (9) :3652-7.|[3]Widemann BC, et al., Pharmacokinetics and metabolism of the methotrexate metabolite 2, 4-diamino-N (10) -methylpteroic acid. J Pharmacol Exp Ther. 2000 Sep;294 (3) :894-901.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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