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Methotrexate (hydrate)

CAT: 0804-HY-14519B-01Size: 1 gDry Ice: NoHazardous: No
CAT#:0804-HY-14519B-01Size:1 g
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Methotrexate hydrate is a substance that affects cell growth and division. It is commonly used to fight certain diseases, especially cancer and autoimmune diseases. It works by inhibiting the process by which cells synthesize DNA.
CAS Number
[133073-73-1]
Product Name Alternative
Amethopterin (hydrate) ; CL14377 (hydrate) ; WR19039 (hydrate)
UNSPSC
12352200
Hazard Statement
H301, H315, H319, H360
Target
Antibiotic; Bacterial; Biochemical Assay Reagents
Type
Biochemical Assay Reagents
Related Pathways
Anti-infection; Others
Applications
COVID-19-immunoregulation
Field of Research
Others; Cancer
Assay Protocol
https://www.medchemexpress.com/methotrexate-hydrate.html
Purity
99.93
Solubility
DMSO : 10 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
NC1=NC(N)=C2C(N=CC(CN(C)C3=CC=C(C(N[C@@H](CCC(O)=O)C(O)=O)=O)C=C3)=N2)=N1.O.[x]
Molecular Formula
C20H22N8O5.xH2O
Precautions
H301, H315, H319, H360
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Biochemical Assay Reagents
Clinical Information
Launched
Citation 01
Biomater Res. 2025 Sep 3:29:0245.|ACS Omega. 2025 Oct 29;10 (44) :52562–52575.|Acta Biomater. 2025 Aug 27:S1742-7061 (25) 00640-3.|Acta Pharmacol Sin. 2021 Jan;42 (1) :108-114.|Acta Pharmacol Sin. 2025 Jun;46 (6) :1733-1741.|Adv Mater. 2025 Jul 4:e2505231.|Anticancer Res. 2024 Jul;44 (7) :2787-2792.|Anticancer Res. 2024 Oct;44 (10) :4213-4218.|Arthritis Res Ther. 2022 Jan 19;24 (1) :27.|Authorea. 2025 Jan 03.|Biochem Biophys Rep. 2021 Nov 26:28:101177.|Biomed Pharmacother. 2024 Jul 19:178:117167.|bioRxiv. 2025 Nov 20.|Biotechnol Bioeng. 2021 Dec;118 (12) :4687-4698.|Cancers (Basel) . 2022 Oct 19;14 (20) :5127.|Cancers. 2019 Oct 25;11 (11) :1654.|Cell Death Dis. 2020 Nov 12;11 (11) :976.|Cell Death Dis. 2024 May 20;15 (5) :349.|Cell Death Dis. 2025 Nov 24;16 (1) :852.|Cell Death Dis. 2025 Nov 24;16 (1) :856.|Cell Rep Med. 2025 Apr 2:102053.|Cell Rep Methods. 2023 Oct 23;3 (10) :100599.|Chem Res Toxicol. 2025 Feb 17;38 (2) :281-295.|Commun Biol. 2022 Jun 23;5 (1) :619.|Dis Model Mech. 2023 Mar 1;16 (3) :dmm049769.|Ecotoxicol Environ Saf. 2025 Nov 15:307:119433.|EMBO Mol Med. 2022 Mar 7;14 (3) :e14552.|EMBO Mol Med. 2025 Oct 13.|Eur J Pharm Sci. 2025 Sep 27:214:107296.|Eur J Pharmacol. 2023 Dec 15:961:176162.|Guidelines and Standards in Chinese Medicine. 2024 Dec.|Int Immunopharmacol. 2023 Feb:115:109689.|Int Immunopharmacol. 2023 Nov 15;125 (Pt B) :111175.|Int Immunopharmacol. 2024 Jun 15:134:112183.|Int Immunopharmacol. 2025 Apr 26:156:114735.|Int Immunopharmacol. 2025 May 23:159:114894.|Int J Immunopathol Pharmacol. 2025 Jan-Dec:39:3946320251348715.|J Adv Res. 2025 Aug:74:609-620.|J Biol Chem. 2019 Dec 27;294 (52) :20084-20096. |J Bone Oncol. 2021 Sep 20:30:100391.|J Clin Invest. 2023 Jul 3;133 (13) :e169993.|J Exp Clin Cancer Res. 2024 Dec 26;43 (1) :330.|J Mol Med (Berl) . 2019 Aug;97 (8) :1183-1193.|J Nanobiotechnology. 2024 Mar 3;22 (1) :89.|J Pharm Anal. 2022 Dec;12 (6) :879-888.|Lung. 2024 Nov 27;203 (1) :4.|Mediators Inflamm. 2024 Dec 5:2024:1995952.|Micromachines. 2021 Jun 10;12 (6) :681.|Mol Biomed. 2025 Nov 21;6 (1) :114.|Mol Cancer. 2024 Apr 29;23 (1) :86.|Mol Cancer. 2024 Jan 10;23 (1) :12.|Nat Commun. 2025 Feb 28;16 (1) :2071.|Oncotarget. 2017 Dec 2;8 (68) :112313-112329.|Patent. US20170128439A1.|Patent. US20250235423A1.|Phytomedicine. 2022 Jun;100:154068.|Plasma Process Polym. 2021 Feb 12.|Queen’s University. Department of Biomedical Molecular Sciences. 2021 Oct.|Redox Biol. 2024 Dec 25:79:103482.|Research Square Preprint. 2023 Dec 1.|Research Square Preprint. 2023 Dec 4.|Rheumatology (Oxford) . 2025 Aug 13:keaf437.|Sci Rep. 2018 Jun 21;8 (1) :9472. |Sci Rep. 2024 Oct 31;14 (1) :26224.|Sci Signal. 2024 Nov 26;17 (864) :eadp1375.|Small. 2022 Jul;18 (30) :e2202337.|SSRN. 2025 Oct 10.|Toxicology. 2020 May 15;437:152445.|Cell Rep. 2025 Mar 25;44 (4) :115466.|Mol Immunol. 2025 Apr 16:182:83-95.|Sci Data. 2024 Sep 19;11 (1) :1024.

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