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Methotrexate-γ-aspartate

CAT: 0804-HY-148994Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-148994Size:1 Each
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Description
Methotrexate-γ-aspartate is a Ll210 cell dihydrofolate reductase inhibitor. Methotrexate-γ-aspartate is apparently more resistant to enzymic cleavage than is methotrexate-y-glutamate. Methotrexate-γ-aspartate can be used in antibody-targeted liposomes and is promising for research of leukemic[1].
CAS Number
64801-58-7
UNSPSC
12352005
Target
Dihydrofolate reductase (DHFR)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/methotrexate-γ-aspartate.html
Smiles
NC1=NC(N)=NC2=C1N=C(CN(C3=CC=C(C=C3)C(N[C@H](C(O)=O)CCC(N[C@H](C(O)=O)CC(O)=O)=O)=O)C)C=N2
Molecular Formula
C24H27N9O8
Molecular Weight
569.53
References & Citations
[1]Sirotnak FM, et al. Growth inhibitory, transport and biochemical properties of the gamma-glutamyl and gamma-aspartyl peptides of methotrexate in L1210 leukemia cells in vitro. Biochem Pharmacol. 1978;27 (14) :1821-5.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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