L-Thyroxine sodium xhydrate

• UNSPSC Description:

  L-Thyroxine sodium xhydrate (Levothyroxine; T4) is a synthetic hormone in the treatment of hypothyroidism. DIO enzymes convert biologically active hormone (Triiodothyronine,T3) from L-Thyroxine (T4).

• Target Antigen:

  Thyroid Hormone Receptor

• Type:

  Biochemical Assay Reagents

• Related Pathways:

  Vitamin D Related/Nuclear Receptor

• Applications:

  Metabolism-protein/nucleotide metabolism

• Field of Research:

  Endocrinology

• Assay Protocol:

  https://www.medchemexpress.com/L-Thyroxine_sodium_xhydrate.html

• Purity:

  99.30

• Solubility:

  0.01 M NaOH : 2 mg/mL (ultrasonic;warming;adjust pH to 12 with NaOH;heat to 60°C)

• Smiles:

  IC1=C(O)C(I)=CC(OC2=C(I)C=C(C[C@@](N)([H])C(O[Na])=O)C=C2I)=C1.O

• Molecular Weight:

  816.87

• References & Citations:

  [1]Arici M, et al. Association between genetic polymorphism and levothyroxine bioavailability in hypothyroid patients. Endocr J. 2018 Jan 11.|[2]Corriveau S, et al. Levothyroxine treatment generates an abnormal uterine contractility patterns in an in vitro animalmodel. J Clin Transl Endocrinol. 2015 Sep 9;2(4):144-149.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Clinical Information:

  Phase 4

• CAS Number:

  25416-65-3