Products for Research Use Only
RegisterLogin

ONO-AE3-208

CAT: 0804-HY-50901-01Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-50901-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
ONO-AE3-208 is a selective and orally active EP4 receptor antagonist with a Ki of 1.3 nM. ONO-AE3-208 shows less potently affects EP3, FP, and TP receptors (Ki of 30 nM, 790 nM, and 2400 nM, respectively) . ONO-AE3-208 suppresses cell invasion, migration, and metastasis of prostate cancer[1][2].
CAS Number
402473-54-5
Product Name Alternative
AE 3-208
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Prostaglandin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Cancer-programmed cell death
Field of Research
Cancer; Endocrinology
Assay Protocol
https://www.medchemexpress.com/ONO-AE3-208.html
Concentration
10mM
Purity
98.65
Solubility
DMSO : 33.33 mg/mL (ultrasonic)
Smiles
N#CC1=CC=C(C(NC(C(C2=C3C=CC=CC3=C(F)C=C2)C)=O)=C1)CCCC(O)=O
Molecular Formula
C24H21FN2O3
Molecular Weight
404.43
Precautions
H302, H315, H319, H335
References & Citations
[1]Xu S, et al. An EP4 Antagonist ONO-AE3-208 Suppresses Cell Invasion, Migration, and Metastasis of Prostate Cancer. Cell Biochem Biophys. 2014 Apr 18.|[2]Ren Y, et al. Prostaglandin E2 mediates connecting tubule glomerular feedback. Hypertension. 2013 Dec;62 (6) :1123-8.|[3]Xu S, et al. Inhibitory effect of ONO-AE3-208 on the formation of bone metastasis of prostate cancer in mice. Zhonghua Nan Ke Xue. 2014 Aug;20 (8) :684-9.|[4]Thieme K, et al. EP4 inhibition attenuates the development of diabetic and non-diabetic experimental kidney disease. Sci Rep. 2017 Jun 13;7 (1) :3442.|[5]Kenji Kabashima, et al. The prostaglandin receptor EP4 suppresses colitis, mucosal damage and CD4 cell activation in the gut. J Clin Invest. 2002 Apr;109 (7) :883-93.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
EP; FP; TXA2/TP

Related Products

CatalogName
HY-179004ONO-9517601
HY-117444-01ONO-9780307
HY-112788-01ONO-8590580
HY-123816ONO 2050297
HY-150204-01ONO-0740556
HY-19101-01ONO-3307
HY-164517ONO-7579
HY-123542ONO-3403
HY-114841-01ONO 207
HY-113635ONO-6240

Alternative Products

CatalogName
A3684-5ONO-AE3-208
3565/50ONO AE3 208
T84444-01ONO-AE3-208 sodium
A11516-100ONO-AE3-208 100mg
A11516-50ONO-AE3-208 50mg
A11516-10ONO-AE3-208 10mg
A11516-25ONO-AE3-208 25mg
A11516-5ONO-AE3-208 5mg
A11516-2ONO-AE3-208 2mg

Popular Products