ONO-8130

CAT: 0804-HY-110198Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-110198Size:1 mg
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Description
ONO-8130 is an orally active and selective prostanoid EP1 receptor antagonist. ONO-8130 blocks phosphorylation of ERK in the L6 spinal cord. ONO-8130 relieves bladder pain in mice with cyclophosphamide-induced cystitis. ONO-8130 can be used for interstitial cystitis research[1].
CAS Number
[459841-96-4]
UNSPSC
12352005
Target
PERK; Prostaglandin Receptor
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; GPCR/G Protein
Applications
COVID-19-anti-virus
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/ono-8130.html
Solubility
10 mM in DMSO
Smiles
O=[S](N(C(C=C(CCC1)C1=C2)=C2OCC(C=C3)=CC=C3C(O)=O)CC(C)C)(C4=NC(C)=CS4)=O
Molecular Formula
C25H28N2O5S2
Molecular Weight
500.63
References & Citations
[1]Miki T, et al. ONO-8130, a selective prostanoid EP1 receptor antagonist, relieves bladder pain in mice with cyclophosphamide-induced cystitis. Pain. 2011 Jun;152 (6) :1373-1381.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
EP

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