ONO-8130

• Description :

  ONO-8130 is an orally active and selective prostanoid EP1 receptor antagonist. ONO-8130 blocks phosphorylation of ERK in the L6 spinal cord. ONO-8130 relieves bladder pain in mice with cyclophosphamide-induced cystitis. ONO-8130 can be used for interstitial cystitis research[1].

• UNSPSC :

  12352005

• Target :

  PERK; Prostaglandin Receptor

• Type :

  Reference compound

• Related Pathways :

  Cell Cycle/DNA Damage; GPCR/G Protein

• Applications :

  COVID-19-anti-virus

• Field of Research :

  Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/ono-8130.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=[S](N(C(C=C(CCC1)C1=C2)=C2OCC(C=C3)=CC=C3C(O)=O)CC(C)C)(C4=NC(C)=CS4)=O

• Molecular Formula :

  C25H28N2O5S2

• Molecular Weight :

  500.63

• References & Citations :

  [1]Miki T, et al. ONO-8130, a selective prostanoid EP1 receptor antagonist, relieves bladder pain in mice with cyclophosphamide-induced cystitis. Pain. 2011 Jun;152 (6) :1373-1381.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  EP

• CAS Number :

  [459841-96-4]