ONO-3307

• Description :

  ONO-3307 is a protease inhibitor that competitively inhibits a variety of proteases including trypsin, thrombin, plasma kallikrein, plasmin, pancreatic kallikrein, and chymotrypsin. ONO-3307 alleviates endotoxin-induced experimental disseminated intravascular coagulation (DIC) in rats. ONO-3307 can be used in the study of thrombosis and protease-mediated diseases[1][2].

• UNSPSC :

  12352005

• Target :

  Kallikrein

• Type :

  Reference compound

• Related Pathways :

  Immunology/Inflammation

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Cardiovascular Disease

• Assay Protocol :

  https://www.medchemexpress.com/ono-3307.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C(OC1=CC=C(S(=O)(N)=O)C=C1)C2=CC=C(NC(N)=N)C=C2.CS(=O)(O)=O

• Molecular Formula :

  C15H18N4O7S2

• Molecular Weight :

  430.46

• References & Citations :

  [1]Yoshikawa T, et al. Protective effects of ONO-3307, a new synthetic protease inhibitor against experimental disseminated intravascular coagulation in rats. Thromb Res. 1990 Oct 1;60 (1) :1-7.|[2]Matsuoka S, et al. Inhibitory effects of ONO-3307 on various proteases and tissue thromboplastin in vitro and on experimental thrombosis in vivo. Jpn J Pharmacol. 1989 Dec;51 (4) :455-63.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  Phase 2

• CAS Number :

  [76472-29-2]