ONO-3307

• Description:

  ONO-3307 is a protease inhibitor that competitively inhibits a variety of proteases including trypsin, thrombin, plasma kallikrein, plasmin, pancreatic kallikrein, and chymotrypsin. ONO-3307 alleviates endotoxin-induced experimental disseminated intravascular coagulation (DIC) in rats. ONO-3307 can be used in the study of thrombosis and protease-mediated diseases[1][2].

• UNSPSC:

  12352005

• Target:

  Kallikrein

• Type:

  Reference compound

• Related Pathways:

  Immunology/Inflammation

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Cardiovascular Disease

• Assay Protocol:

  https://www.medchemexpress.com/ono-3307.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C (OC1=CC=C (S (=O) (N) =O) C=C1) C2=CC=C (NC (N) =N) C=C2.CS (=O) (O) =O

• Molecular Formula:

  C15H18N4O7S2

• Molecular Weight:

  430.46

• References & Citations:

  [1]Yoshikawa T, et al. Protective effects of ONO-3307, a new synthetic protease inhibitor against experimental disseminated intravascular coagulation in rats. Thromb Res. 1990 Oct 1;60 (1) :1-7.|[2]Matsuoka S, et al. Inhibitory effects of ONO-3307 on various proteases and tissue thromboplastin in vitro and on experimental thrombosis in vivo. Jpn J Pharmacol. 1989 Dec;51 (4) :455-63.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  Phase 2

• CAS Number:

  76472-29-2