ONO-2570366

• Description:

  ONO-2570366 (Compound 11a) is an antagonist of the cysteinyl leukotriene receptors CysLT1R and CysLT2R (IC50 = 14 nM) . ONO-2570366 inhibits the binding of LTD4[1].

• UNSPSC:

  12352005

• Target:

  Leukotriene Receptor

• Related Pathways:

  GPCR/G Protein

• Field of Research:

  Inflammation/Immunology

• Smiles:

  O=C (O) [C@H]1OC2=C (C=CC=C2N (C1) CCCC (O) =O) NC (C3=CC=C (C=C3) OCCCCC4=CC (F) =CC=C4Cl) =O

• Molecular Formula:

  C30H30ClFN2O7

• Molecular Weight:

  585.02

• References & Citations:

  [1]Gusach A, et al. Structural basis of ligand selectivity and disease mutations in cysteinyl leukotriene receptors. Nat Commun. 2019 Dec 6;10 (1) :5573.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  LTC4/CysLT2; LTD4/CysLT1