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ONO-2570366

CAT: 0804-HY-176921Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-176921Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ONO-2570366 (Compound 11a) is an antagonist of the cysteinyl leukotriene receptors CysLT1R and CysLT2R (IC50 = 14 nM) . ONO-2570366 inhibits the binding of LTD4[1].
UNSPSC
12352005
Target
Leukotriene Receptor
Related Pathways
GPCR/G Protein
Field of Research
Inflammation/Immunology
Smiles
O=C(O)[C@H]1OC2=C(C=CC=C2N(C1)CCCC(O)=O)NC(C3=CC=C(C=C3)OCCCCC4=CC(F)=CC=C4Cl)=O
Molecular Formula
C30H30ClFN2O7
Molecular Weight
585.02
References & Citations
[1]Gusach A, et al. Structural basis of ligand selectivity and disease mutations in cysteinyl leukotriene receptors. Nat Commun. 2019 Dec 6;10 (1) :5573.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
LTC4/CysLT2; LTD4/CysLT1

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