ONO-2570366

• Description :

  ONO-2570366 (Compound 11a) is an antagonist of the cysteinyl leukotriene receptors CysLT1R and CysLT2R (IC50 = 14 nM) . ONO-2570366 inhibits the binding of LTD4[1].

• UNSPSC :

  12352005

• Target :

  Leukotriene Receptor

• Related Pathways :

  GPCR/G Protein

• Field of Research :

  Inflammation/Immunology

• Smiles :

  O=C(O)[C@H]1OC2=C(C=CC=C2N(C1)CCCC(O)=O)NC(C3=CC=C(C=C3)OCCCCC4=CC(F)=CC=C4Cl)=O

• Molecular Formula :

  C30H30ClFN2O7

• Molecular Weight :

  585.02

• References & Citations :

  [1]Gusach A, et al. Structural basis of ligand selectivity and disease mutations in cysteinyl leukotriene receptors. Nat Commun. 2019 Dec 6;10 (1) :5573.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  LTC4/CysLT2; LTD4/CysLT1