ONO-2920632

CAT: 0804-HY-172182-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-172182-01Size:5 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ONO-2920632 is an orally active and central nervous system (CNS) -penetrant TREK activator, with EC50 values of 0.3 µM and 2.8 μM for TREK-1 and TREK-2, respectively. ONO-2920632 exhibits selectivity for other K2P channels (>91-fold selective versus TASK1, TASK2, TASK3, TRAAK, and TWIK2; 31-fold selective versus TRESK) . ONO-2920632 possesses analgesic effects and can be used in research on pain, migraine, and neurological disorders.
CAS Number
[2230296-66-7]
Product Name Alternative
VU6011887
UNSPSC
12352005
Target
Potassium Channel
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Purity
99.11
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C1=CN2C(C=C1)=NC=N2)NCC3=CC=C(OC(F)(F)F)C=C3F
Molecular Formula
C15H10F4N4O2
Molecular Weight
354.26
References & Citations
[1]Yashiro K, et al. Discovery of ONO-2920632 (VU6011887) : A Highly Selective and CNS Penetrant TREK-2 (TWIK-Related K+ Channel 2) Preferring Activator In Vivo Tool Compound. ACS Chem Neurosci. 2025 Mar 5;16 (5) :960-967.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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