ONO-2920632

• Description:

  ONO-2920632 is an orally active and central nervous system (CNS) -penetrant TREK activator, with EC50 values of 0.3 µM and 2.8 μM for TREK-1 and TREK-2, respectively. ONO-2920632 exhibits selectivity for other K2P channels (>91-fold selective versus TASK1, TASK2, TASK3, TRAAK, and TWIK2; 31-fold selective versus TRESK) . ONO-2920632 possesses analgesic effects and can be used in research on pain, migraine, and neurological disorders.

• Product Name Alternative:

  VU6011887

• UNSPSC:

  12352005

• Target:

  Potassium Channel

• Related Pathways:

  Membrane Transporter/Ion Channel

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Purity:

  99.11

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  O=C (C1=CN2C (C=C1) =NC=N2) NCC3=CC=C (OC (F) (F) F) C=C3F

• Molecular Formula:

  C15H10F4N4O2

• Molecular Weight:

  354.26

• References & Citations:

  [1]Yashiro K, et al. Discovery of ONO-2920632 (VU6011887) : A Highly Selective and CNS Penetrant TREK-2 (TWIK-Related K+ Channel 2) Preferring Activator In Vivo Tool Compound. ACS Chem Neurosci. 2025 Mar 5;16 (5) :960-967.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  2230296-66-7