ONO-1714

• Description:

  ONO-1714 is an orally active nitric oxide synthase inhibitor. ONO-1714 attenuates endotoxin-induced acute lung injury, reduces intestinal ischemia–reperfusion injury, represses biliary carcinogenesis[1][2][3].

• UNSPSC:

  12352005

• Target:

  NO Synthase

• Related Pathways:

  Immunology/Inflammation

• Field of Research:

  Cancer; Inflammation/Immunology; Cardiovascular Disease

• Smiles:

  Cl[C@@H]1[C@@]2([H])[C@]1([H])N=C(C[C@@H]2C)N.Cl

• Molecular Formula:

  C7H12Cl2N2

• Molecular Weight:

  195.09

• References & Citations:

  [1]Mishima T, et al. Chemopreventative effect of an inducible nitric oxide synthase inhibitor, ONO-1714, on inflammation-associated biliary carcinogenesis in hamsters. Carcinogenesis. 2009 Oct;30 (10) :1763-7.|[2]Naito Y, et al. A novel potent inhibitor of inducible nitric oxide inhibitor, ONO-1714, reduces intestinal ischemia-reperfusion injury in rats. Nitric Oxide. 2004 May;10 (3) :170-7. |[3]Mikawa K, et al. ONO-1714, a nitric oxide synthase inhibitor, attenuates endotoxin-induced acute lung injury in rabbits. Anesth Analg. 2003 Dec;97 (6) :1751-1755.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  214479-33-1