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MAGL-IN-222

CAT: 0804-HY-173296Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-173296Size:1 Each
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Description
MAGL-IN-222 (Compound ZQ-7) is a covalent inhibitor targeting monoacylglycerol lipase (MAGL) with an IC50 of 42.31 μM. MAGL-IN-222 can reduce the breakdown of 2-arachidonoylglycerol (2-AG) and increase the intracellular 2-AG level, thereby inhibiting the proliferation and migration of MDA-MB-231 breast cancer cells. MAGL-IN-222 can be used in the research of breast cancer and other related diseases[1].
CAS Number
877804-65-4
UNSPSC
12352005
Target
Lipase
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Cancer
Smiles
CC(/C(C(N1C2CCS(C2)(=O)=O)=O)=C/C3=CC=C(N(CC)CC)C=C3)=C(C#N)C1=O
Molecular Formula
C22H25N3O4S
Molecular Weight
427.52
References & Citations
[1]Wang J, et al. Discovery of new covalent inhibitors of monoacylglycerol lipase with the nitrile warhead via SCARdock. Bioorg Chem. 2025 Mar 15;159:108378.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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