MD-222

CAT: 0804-HY-134823-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-134823-01Size:1 mg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
MD-222 is the first-in-class highly potent PROTAC degrader of MDM2. MD-222 consists of ligands for Cereblon and MDM2. MD-222 induces rapid degradation of the MDM2 protein and activation of wild-type p53 in cells. MD-222 has anticancer effects[1][2].
CAS Number
[2136246-72-3]
UNSPSC
12352005
Target
E1/E2/E3 Enzyme; MDM-2/p53; PROTACs
Type
Reference compound
Related Pathways
Apoptosis; Metabolic Enzyme/Protease; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/md-222.html
Purity
99.81
Solubility
DMSO : 200 mg/mL (ultrasonic)
Smiles
O=C1[C@]2(C3=CC=C(Cl)C=C3N1)C4(CCCCC4)N[C@H]([C@]2([H])C5=C(C(Cl)=CC=C5)F)C(NC6=CC=C(C=C6)C(NCCCCCC7=C8C(C(N(C9C(NC(CC9)=O)=O)C8)=O)=CC=C7)=O)=O
Molecular Formula
C48H47Cl2FN6O6
Molecular Weight
893.83
References & Citations
[1]Jiuling Yang, et al. Simple Structural Modifications Converting a Bona fide MDM2 PROTAC Degrader into a Molecular Glue Molecule: A Cautionary Tale in the Design of PROTAC Degraders. J Med Chem. 2019 Nov 14;62 (21) :9471-9487.|[2]Li Y, et al. Discovery of MD-224 as a First-in-Class, Highly Potent, and Efficacious Proteolysis TargetingChimera Murine Double Minute 2 Degrader Capable of Achieving Complete and Durable TumorRegression. J Med Chem. 2019 Jan 24;62 (2) :448-466.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MDM2

Related Products

CatalogName
HY-174458MD-4251
HY-124464MD 770222
HY-117394-01MD 85
HY-169327-01MD-265
HY-114312-01MD-224
HY-172125AMPRO-222
HY-105431ASI-222
HY-125080BIBS-222
HY-111150AMG-222
HY-173296MAGL-IN-222

Alternative Products

CatalogName
MBS5798034MD-222
MBS579262VX-222 (VCH-222, Lomibuvir)
MBS3611907-01MD-224
M20076-01MD 69276
MBS5811343MD 780236
24426MD Antibody
103-M435MD-1
MF-0118021-01MD-4251
MF-0144933-01MD-230254
abx412038Protein MD-2 (MD-2) Antibody

Popular Products