Quinidine polygalacturonate

CAT: 0804-HY-B1751ESize: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-B1751ESize:1 Each
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Description
Quinidine polygalacturonate is an antiarrhythmic agent. Quinidine polygalacturonate is a potent, orally active, selective cytochrome P450db inhibitor. Quinidine polygalacturonate is also a K+ channel blocker with an IC50 of 19.9 μM, and can induce apoptosis. Quinidine polygalacturonate can be used for malaria research[1][2][3][4].
CAS Number
[27555-34-6]
UNSPSC
12352005
Target
Apoptosis; Cytochrome P450; Parasite; Potassium Channel
Type
Reference compound
Related Pathways
Anti-infection; Apoptosis; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Infection; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/quinidine-polygalacturonate.html
Solubility
10 mM in DMSO
Smiles
O=C[C@H](O)[C@@H](O)[C@@H](O)[C@H](O)C(O)=O.O[C@H]([C@]1([H])[N@@]2C[C@H](C=C)[C@@H](CC2)C1)C3=CC=NC4=CC=C(OC)C=C34.[n].[n]
Molecular Formula
C20H24N2O2.x (C6H10O7) x
References & Citations
[1]Kehl SJ, et al. Quinidine-induced inhibition of the fast transient outward K+ current in rat melanotrophs. Br J Pharmacol. 1991 Jul;103 (3) :1807-13.|[2]Roden DM, et al. Class I antiarrhythmic agents: quinidine, procainamide and N-acetylprocainamide, disopyramide. Pharmacol Ther. 1983;23 (2) :179-91.|[3]Sang-Yun Lee, et al. Hydrocinchonine, cinchonine, and quinidine potentiate paclitaxel-induced cytotoxicity and apoptosis via multidrug resistance reversal in MES-SA/DX5 uterine sarcoma cells. Environ Toxicol. 2011 Aug;26 (4) :424-31.|[4]Hassan Jamali, et al. Effect of dextromethorphan/quinidine on pentylenetetrazole- induced clonic and tonic seizure thresholds in mice. Neurosci Lett. 2020 Jun 11;729:134988.|[5]Moody DE, et al. Quinidine inhibits in vivo metabolism of amphetamine in rats: impact upon correlation between GC/MS and immunoassay findings in rat urine. J Anal Toxicol. 1990 Sep-Oct;14 (5) :311-7.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
Plasmodium

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