Quinidine

CAT: 0804-HY-B1751H-01Size: 50 mgDry Ice: NoHazardous: No
CAT#:0804-HY-B1751H-01Size:50 mg
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CAS Number
[56-54-2]
UNSPSC Description
Quinidine is a stereoisomer of Quinine (HY-D0143), a natural compound derived from the bark of the South American cinchona tree. Quinidine is one of the earliest known antiarrhythmic agents and is available as a Class 1a antiarrhythmic and antimalarial drug. Quinidine inhibits the rapid inward sodium current, resulting in the suppression of action potential phase 0. This mechanism suppresses the excitability of the heart muscle, ultimately leading to longer duration of action potentials and reduced automaticity. Quinidine shows a "use-dependent blocking" effect on the rapidly inward sodium current, meaning that the drug's effects increases at higher heart rates and decreases at lower heart rates.Quinidine can be used in the study of Plasmodium falciparum malaria and ventricular arrhythmias[1].
Target Antigen
Parasite; Sodium Channel
Type
Natural Products
Related Pathways
Anti-infection;Membrane Transporter/Ion Channel
Applications
COVID-19-immunoregulation
Field of Research
Infection; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/quinidine-1.html
Purity
80.0
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
C=C[C@H]1C[N@](CC[C@H]1C2)[C@@]2([H])[C@@H](O)C3=CC=NC4=CC=C(OC)C=C34
Molecular Weight
324.42
References & Citations
[1]Jain A, et al. Quinidine. [Updated 2023 Aug 2]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan-.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen)
Clinical Information
No Development Reported

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