Quinidine (sulfate)

Quinidine (sulfate)

• CAS Number: 50-54-4
• UNSPSC Description: Quinidine Monosulfate is an antiarrhythmic agent. Quinidine Monosulfate is a potent, orally active, selective cytochrome P450db inhibitor. Quinidine Monosulfate is also a K+ channel blocker with an IC50 of 19.9 μM, and can induce apoptosis. Quinidine Monosulfate can be used for malaria research[1][2][3][4].
• Target Antigen: Apoptosis; Cytochrome P450; Parasite; Potassium Channel
• Type: Reference compound
• Related Pathways: Anti-infection;Apoptosis;Membrane Transporter/Ion Channel;Metabolic Enzyme/Protease
• Applications: COVID-19-immunoregulation
• Field of Research: Cancer; Infection; Cardiovascular Disease
• Assay Protocol: https://www.medchemexpress.com/quinidine-sulfate.html
• Solubility: 10 mM in DMSO
• Smiles: O=S(O)(O)=O.C=C[C@H]1C[N@](CC[C@H]1C2)[C@@]2([H])[C@@H](O)C3=CC=NC4=CC=C(OC)C=C34.[0.5]
• Molecular Weight: 373.46
• References & Citations: [1]Kehl SJ, et al. Quinidine-induced inhibition of the fast transient outward K+ current in rat melanotrophs. Br J Pharmacol. 1991 Jul;103(3):1807-13.|[2]Roden DM, et al. Class I antiarrhythmic agents: quinidine, procainamide and N-acetylprocainamide, disopyramide.|[3]Sang-Yun Lee, et al. Hydrocinchonine, cinchonine, and quinidine potentiate paclitaxel-induced cytotoxicity and apoptosis via multidrug resistance reversal in MES-SA/DX5 uterine sarcoma cells. Environ Toxicol. 2011 Aug;26(4):424-31.|[4]Hassan Jamali, et al. Effect of dextromethorphan/quinidine on pentylenetetrazole- induced clonic and tonic seizure thresholds in mice. Neurosci Lett. 2020 Jun 11;729:134988.|[5]Moody DE, et al. Quinidine inhibits in vivo metabolism of amphetamine in rats: impact upon correlation between GC/MS and immunoassay findings in rat urine. J Anal Toxicol. 1990 Sep-Oct;14(5):311-7.Nat Commun. 2024 Jun 19.|AAPS J. 2021 Jun 28;23(4):91.|Andrology. 2024 Nov 05.|Chemosphere. 2021, 131347.|Environ Int. 2019 Jun;127:694-703. |Environ Pollut. 2024 May 25:124214.|Eur J Drug Metab Pharmacokinet. 2022 Jun 22.|Food Chem Toxicol. 2022 Sep 15;113431.|Front Pharmacol. 2020 Jul 31;11:1038.|J Agric Food Chem. 2022 Feb 21.|J Anim Sci. 2022 Mar 5;skac069.|J Hazard Mater. 2021 Aug 15;416:125764.|J Med Chem. 2020 Oct 8;63(19):11085-11099.|J Med Chem. 2021 Mar 11;64(5):2725-2738.|Pharmacol Res Perspect. 2020 Apr;8(2):e00575.|Pharmacol Res Perspect. 2021 Oct;9(5):e00879.|RSC Adv. 2019, 9(28):16136-16146.|Virol J. 2024 Aug 8;21(1):181.
• Shipping Conditions: Room temperature
• Clinical Information: Launched