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Sulfo-SPDB-DGN462

CAT: 0804-HY-136291Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-136291Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Sulfo-SPDB-DGN462 is a agent-linker conjugate for ADC. Sulfo-SPDB-DGN462 consists a toxin DGN462 conjugated to the cleavable Sulfo-SPDB linker. DGN462, a potent DNA-alkylating agent, shows anti-tumor activity, such as acute myeloid leukemia (AML).
UNSPSC
12352203
Target
Drug-Linker Conjugates for ADC
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/sulfo-spdb-dgn462.html
Solubility
10 mM in DMSO
Smiles
O=C1N2[C@](CC3=C2C=CC=C3)([H])CNC4=CC(OCC5=CC(N(C(C(C)(C)SSCCC(S(=O)(O)=O)C(ON6C(CCC6=O)=O)=O)=O)CCOCCOCCOC)=CC(COC7=C(OC)C=C8C(N9[C@](CC%10=C9C=CC=C%10)([H])C=NC8=C7)=O)=C5)=C(OC)C=C14
Molecular Formula
C61H66N6O17S3
Molecular Weight
1251.40
References & Citations
[1]Hicks SW, et al. The novel CD19-targeting antibody-drug conjugate huB4-DGN462 shows improved anti-tumor activity compared to SAR3419 in CD19-positive lymphoma and leukemia models. Haematologica. 2019 Aug;104 (8) :1633-1639.
Shipping Conditions
Room temperature
Scientific Category
ADC Related
Clinical Information
No Development Reported
Isoform
Maytansinoids

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