LC-PEG8-SPDP

• Description :

  LC-PEG8-SPDP is a cleavable ADC linker used for the antibody-drug conjugates (ADCs) [1].

• UNSPSC :

  12352203

• Hazard Statement :

  H302-H315-H319-H335

• Target :

  ADC Linker

• Type :

  ADC Related

• Related Pathways :

  Antibody-drug Conjugate/ADC Related

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/lc-peg8-spdp.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C(ON1C(CCC1=O)=O)CCOCCOCCOCCOCCOCCOCCOCCOCCNC(CCSSC2=NC=CC=C2)=O

• Molecular Formula :

  C31H49N3O13S2

• Molecular Weight :

  735.86

• Precautions :

  P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

• References & Citations :

  [1]Zhao RY, et al. Synthesis and evaluation of hydrophilic linkers for antibody-maytansinoid conjugates. J Med Chem. 2011 May 26;54 (10) :3606-23.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  ADC Related

• Clinical Information :

  No Development Reported

• Isoform :

  Cleavable Linker; Disulfide Cleavable Linker

• CAS Number :

  [1252257-56-9]