SPDP

• Description :

  SPDP (SPDP Crosslinker) is a short-chain crosslinker for amine-to-sulfhydryl conjugation via NHS-ester and pyridyldithiol reactive groups that form cleavable (reducible) disulfide bonds with cysteine sulfhydryls. It is a glutathione cleavable ADC linker used for the antibody-drug conjugates (ADCs) [1][2].

• Product Name Alternative :

  SPDP Crosslinker; Py-ds-Prp-OSu

• UNSPSC :

  12352203

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  ADC Linker

• Type :

  ADC Related

• Related Pathways :

  Antibody-drug Conjugate/ADC Related

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/SPDP.html

• Purity :

  99.14

• Solubility :

  DMSO : 250 mg/mL (ultrasonic)

• Smiles :

  O=C(ON1C(CCC1=O)=O)CCSSC2=NC=CC=C2

• Molecular Formula :

  C12H12N2O4S2

• Molecular Weight :

  312.37

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Lobedanz S et al. A periplasmic coiled-coil interface underlying TolC recruitment and the assembly of bacterial drug effluxpumps. Proc Natl Acad Sci U S A, 2007 Mar 13, 104 (11) :4612-7.|[2]Karumuthil-Melethil S et al. Dendritic cell-directed CTLA-4 engagement during pancreatic beta cell antigen presentation delays type 1diabetes. J Immunol 2010 Jun 15, 184 (12) :6695-708.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C (Powder, protect from light, stored under nitrogen)

• Scientific Category :

  ADC Related

• Clinical Information :

  No Development Reported

• Isoform :

  Cleavable Linker; Disulfide Cleavable Linker

• CAS Number :

  [68181-17-9]