RegisterLogin

SPDP

CAT: 0804-HY-100216-01Size: 25 mgDry Ice: NoHazardous: No
CAT#:0804-HY-100216-01Size:25 mg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
SPDP (SPDP Crosslinker) is a short-chain crosslinker for amine-to-sulfhydryl conjugation via NHS-ester and pyridyldithiol reactive groups that form cleavable (reducible) disulfide bonds with cysteine sulfhydryls. It is a glutathione cleavable ADC linker used for the antibody-drug conjugates (ADCs) [1][2].
CAS Number
[68181-17-9]
Product Name Alternative
SPDP Crosslinker; Py-ds-Prp-OSu
UNSPSC
12352203
Hazard Statement
H302, H315, H319, H335
Target
ADC Linker
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/SPDP.html
Purity
99.14
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
O=C(ON1C(CCC1=O)=O)CCSSC2=NC=CC=C2
Molecular Formula
C12H12N2O4S2
Molecular Weight
312.37
Precautions
H302, H315, H319, H335
References & Citations
[1]Lobedanz S et al. A periplasmic coiled-coil interface underlying TolC recruitment and the assembly of bacterial drug effluxpumps. Proc Natl Acad Sci U S A, 2007 Mar 13, 104 (11) :4612-7.|[2]Karumuthil-Melethil S et al. Dendritic cell-directed CTLA-4 engagement during pancreatic beta cell antigen presentation delays type 1diabetes. J Immunol 2010 Jun 15, 184 (12) :6695-708.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light, stored under nitrogen)
Scientific Category
ADC Related
Clinical Information
No Development Reported
Isoform
Cleavable Linker; Disulfide Cleavable Linker

Related Products

CatalogName
HY-129374-01SPDH
HY-129371-01SPDV
HY-12448-01SPDB
HY-129370SPDB-sulfo
HY-101151-01Sulfo-SPDB
HY-133542Dimethylamine-SPDB
HY-133550DMAC-SPDB
HY-12460-01SPDB-DM4
HY-P11255SPDI-48-T1
HY-133548NO2-SPDB-sulfo

Alternative Products

CatalogName
MBS3845021-01SPDP
T77286-01DSPE-SPDP
T17834-01DM4-SPDP
MBS5799222SPDP-sulfo
571612SPDP Crosslinker
A20578-25SPDP 25mg
A20578-200SPDP 200mg
A20578-500SPDP 500mg
BA2604-50PEG4-SPDP
A20578-10SPDP 10mg

Popular Products