MDL-100240

CAT: 0804-HY-118264Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-118264Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
MDL-100240 is a dual-acting angiotensin-converting enzyme (ACE) and neutral endopeptidase (NEP) inhibitor. MDL-100240 can significantly lower blood pressure, reverse left ventricular hypertrophy, and effectively prevent hypertrophy and dilatation of the aorta and resistance arteries, with an effect comparable to that of ramipril (HY-B0279) . In addition, MDL-100240 can also reduce aldosterone levels, but has no significant effect on atrial natriuretic peptide and cGMP. In 3-month-old transgenic rats, MDL-100240 can reduce adrenomedullin concentrations, prevent and reverse severe hypertension and cardiovascular damage, and enhance bradykinin effects.
CAS Number
[142695-08-7]
UNSPSC
12352005
Target
Angiotensin-converting Enzyme (ACE) ; Neprilysin
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/mdl-100240.html
Smiles
O=C(O)[C@@H]1CCC[C@@]([H])(N1C2=O)C3=CC=CC=C3C[C@@H]2NC([C@H](CC4=CC=CC=C4)SC(C)=O)=O
Molecular Formula
C26H28N2O5S
Molecular Weight
480.58
References & Citations
[1]Dual ACE and NEP inhibitor MDL-100,240 prevents and regresses severe angiotensin II-dependent hypertension partially through bradykinin type 2 receptor
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2

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