ST-1006

• Description :

  ST-1006 is a potent histamine H4 receptor agonist with a pKi value of 7.94. ST-1006 has anti-inflammatory effect[1][2].

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319

• Target :

  Histamine Receptor

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/st-1006.html

• Purity :

  99.55

• Solubility :

  DMSO : 125 mg/mL (ultrasonic)

• Smiles :

  ClC(C=CC=C1Cl)=C1CNC2=CC(N3CCN(CC3)C)=NC(N)=N2

• Molecular Formula :

  C16H20Cl2N6

• Molecular Weight :

  367.28

• Precautions :

  H302, H315, H319

• References & Citations :

  [1]Adami M, et, al. Differential effects of functionally different histamine H4 receptor ligands on acute irritant dermatitis in mice. Naunyn Schmiedebergs Arch Pharmacol. 2018 Dec;391 (12) :1387-1397.|[2]Mommert S, et, al. Human basophil chemotaxis and activation are regulated via the histamine H4 receptor. Allergy. 2016 Sep;71 (9) :1264-73.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, protect from light)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  H4 Receptor

• CAS Number :

  [1196994-11-2]