W23-1006

• Description :

  W23-1006 is a selective and covalent ALKBH5 inhibitor. W23-1006 binds to the ALKBH5 C200 residue with an IC50 value of 3.848 μM. W23-1006 shows ~30- and 8-fold stronger inhibitory activity than that against FTO and ALKBH3, respectively. W23-1006 can be used for the study of triple-negative breast cancer (TNBC) [1].

• UNSPSC :

  12352005

• Target :

  Anaplastic lymphoma kinase (ALK) ; Apoptosis

• Related Pathways :

  Apoptosis; Protein Tyrosine Kinase/RTK

• Field of Research :

  Cancer

• Purity :

  97.15

• Smiles :

  O=C(/C1=C\C2=CC([N+]([O-])=O)=CC(Br)=C2)NN(C3=CC=C(C=C3)OC)C1=O

• Molecular Formula :

  C17H12BrN3O5

• Molecular Weight :

  418.20

• References & Citations :

  [1]Yang X, et al. Discovery of a Novel Selective and Cell-Active N6-Methyladenosine RNA Demethylase ALKBH5 Inhibitor. J Med Chem. 2025 Feb 27;68 (4) :4133-4147.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C (Powder, stored under nitrogen)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [3035498-92-8]