W23-1006

CAT: 0804-HY-173020-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-173020-01Size:5 mg
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Description
W23-1006 is a selective and covalent ALKBH5 inhibitor. W23-1006 binds to the ALKBH5 C200 residue with an IC50 value of 3.848 μM. W23-1006 shows ~30- and 8-fold stronger inhibitory activity than that against FTO and ALKBH3, respectively. W23-1006 can be used for the study of triple-negative breast cancer (TNBC) [1].
CAS Number
[3035498-92-8]
UNSPSC
12352005
Target
Anaplastic lymphoma kinase (ALK) ; Apoptosis
Related Pathways
Apoptosis; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Purity
97.15
Smiles
O=C(/C1=C\C2=CC([N+]([O-])=O)=CC(Br)=C2)NN(C3=CC=C(C=C3)OC)C1=O
Molecular Formula
C17H12BrN3O5
Molecular Weight
418.20
References & Citations
[1]Yang X, et al. Discovery of a Novel Selective and Cell-Active N6-Methyladenosine RNA Demethylase ALKBH5 Inhibitor. J Med Chem. 2025 Feb 27;68 (4) :4133-4147.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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