ST-401

• Description:

  ST-401, a microtubule-targeting agent (MTA), is a brain-penetrant microtubule (MT) assembly inhibitor. ST-401 disrupts microtubule (MT) function through gentle and reverisible reduction in MT assembly that triggers mitotic delay and cell death in interphase. ST-401 shows a potent antitumor activity[1].

• UNSPSC:

  12352005

• Target:

  Microtubule/Tubulin

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage; Cytoskeleton

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/st-401.html

• Concentration:

  10mM

• Purity:

  99.41

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  OC(C1=CC=CC2=C1C=CC=N2)C3=CC4=C(C=C3)N(CC)C5=CC=CC=C54

• Molecular Formula:

  C24H20N2O

• Molecular Weight:

  352.43

• References & Citations:

  [1]Eric A Horne, et al. A brain-penetrant microtubule-targeting agent that disrupts hallmarks of glioma tumorigenesis. Neurooncol Adv. 2020 Dec 3;3 (1) :vdaa165.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  2419942-78-0