ST-401

• Description :

  ST-401, a microtubule-targeting agent (MTA), is a brain-penetrant microtubule (MT) assembly inhibitor. ST-401 disrupts microtubule (MT) function through gentle and reverisible reduction in MT assembly that triggers mitotic delay and cell death in interphase. ST-401 shows a potent antitumor activity[1].

• UNSPSC :

  12352005

• Target :

  Microtubule/Tubulin

• Type :

  Reference compound

• Related Pathways :

  Cell Cycle/DNA Damage; Cytoskeleton

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/st-401.html

• Concentration :

  10mM

• Purity :

  99.41

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  OC(C1=CC=CC2=C1C=CC=N2)C3=CC4=C(C=C3)N(CC)C5=CC=CC=C54

• Molecular Formula :

  C24H20N2O

• Molecular Weight :

  352.43

• References & Citations :

  [1]Eric A Horne, et al. A brain-penetrant microtubule-targeting agent that disrupts hallmarks of glioma tumorigenesis. Neurooncol Adv. 2020 Dec 3;3 (1) :vdaa165.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [2419942-78-0]