ST-148

CAT: 0804-HY-121663Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-121663Size:1 Each
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ST-148 is a novel small molecule compound that has potent inhibitory effects against all four dengue virus serotypes. In the nonlethal AG129 mouse dengue virus infection model, ST-148 significantly reduced viremia and viral load in vital organs and tended to reduce plasma cytokine levels. Compound resistance was associated with the dengue virus capsid (C) gene, and the direct interaction of ST-148 with the C protein was presumed to be achieved through the protein's built-in fluorescence change in the presence of the compound. Therefore, ST-148 appears to interact with the dengue virus C protein and inhibit one or more unique steps of the viral replication cycle.
CAS Number
[400863-77-6]
UNSPSC
12352005
Hazard Statement
H315-H319
Target
Dengue Virus
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/st-148.html
Smiles
O=C(NC1=NN=C(S1)C2=CC=CC=C2)C3=C(C4=CC5=C(N=C4S3)CCCCC5)N
Molecular Formula
C21H19N5OS2
Molecular Weight
421.54
Precautions
P264-P280-P302+P352-P362+P364
References & Citations
[1]A Novel Inhibitor of Dengue Virus Replication That Targets the Capsid Protein
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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