ST-539

• Description :

  ST-539 is the inhibitor for deubiquitinase USP30 with IC50 of 0.37 μM. ST-539 promotes the ubiquitination of mitochondrial proteins, and induces mitochondrial autophagy, thereby regulating mitochondrial homeostasis. ST-539 can be used in research of neurodegenerative diseases[1].

• UNSPSC :

  12352005

• Target :

  Autophagy; Deubiquitinase

• Related Pathways :

  Autophagy; Cell Cycle/DNA Damage

• Field of Research :

  Neurological Disease

• Smiles :

  O=C(NC1=C2C=CC=C(S(=O)(NC(C)(C)C)=O)C2=CC=C1)C(NC(C3=CC=CC=C3)=O)CC4=CC=CC=C4

• Molecular Formula :

  C30H31N3O4S

• Molecular Weight :

  529.65

• References & Citations :

  [1]Yang P, et al., Mitophagy in Neurodegenerative Diseases: Mechanisms of Action and the Advances of Drug Discovery. J Med Chem. 2025 Feb 27;68 (4) :3970-3994.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [1040754-67-3]