Acetaminophen-d7

• UNSPSC Description:

  Acetaminophen-d7 is the deuterium labeled Acetaminophen. Acetaminophen (Paracetamol) is a selective cyclooxygenase-2 (COX-2) inhibitor with an IC50 of 25.8 μM; is a widely used antipyretic and analgesic agent. Acetaminophen is a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor.

• Target Antigen:

  COX; Endogenous Metabolite; Histone Acetyltransferase

• Type:

  Isotope-Labeled Compounds

• Related Pathways:

  Epigenetics;Immunology/Inflammation;Metabolic Enzyme/Protease

• Field of Research:

  Inflammation/Immunology

• Purity:

  99.0

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  [2H]C([2H])([2H])C(NC1=C([2H])C([2H])=C(C([2H])=C1[2H])O)=O

• Molecular Weight:

  158.21

• References & Citations:

  [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.|[2]Hinz, B, et al. Acetaminophen (paracetamol) is a selective cyclooxygenase-2 inhibitor in man. FASEB J, 2008. 22(2): p. 383-90.|[3]Miroslav Dinić, et al. Lactobacillus fermentum Postbiotic-induced Autophagy as Potential Approach for Treatment ofAcetaminophen Hepatotoxicity. Front Microbiol. 2017 Apr 6;8:594.|[4]Uchida NS, et al. Hepatoprotective Effect of Citral on Acetaminophen-Induced Liver Toxicity in Mice. Evid Based Complement Alternat Med. 2017;2017:1796209.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Clinical Information:

  No Development Reported

• CAS Number:

  1219798-53-4