PROTAC eEF2K degrader-1

• CAS Number:

  2458170-54-0

• UNSPSC Description:

  PROTAC eEF2K degrader-1 (Compound 11l) is an eEF2K-Targeting PROTAC small molecule that induces apoptosis in MDA-MB-231 cells. PROTAC eEF2K degrader-1 mediates eEF2K degradation[1].

• Target Antigen:

  Apoptosis; CaMK; PROTACs

• Type:

  Reference compound

• Related Pathways:

  Apoptosis;Neuronal Signaling;PROTAC

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/protac-eef2k-degrader-1.html

• Solubility:

  DMSO : 25 mg/mL (ultrasonic;warming;heat to 60°C)

• Smiles:

  CCN1C(N(C(C2=C1N=C(C(C(N)=O)=C2)N)=O)CC(NCCOCCNC(COC3=CC=CC4=C3C(N(C4=O)C5CCC(NC5=O)=O)=O)=O)=O)=O

• Molecular Weight:

  707.65

• References & Citations:

  [1]Yao Liu, et al. Designing an eEF2K-Targeting PROTAC small molecule that induces apoptosis in MDA-MB-231 cells. Eur J Med Chem. 2020 Oct 15;204:112505.

• Shipping Conditions:

  Blue Ice

• Clinical Information:

  No Development Reported