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PROTAC eEF2K degrader-1

CAT: 0804-HY-146324-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-146324-01Size:5 mg
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Description
PROTAC eEF2K degrader-1 (Compound 11l) is an eEF2K-Targeting PROTAC small molecule that induces apoptosis in MDA-MB-231 cells. PROTAC eEF2K degrader-1 mediates eEF2K degradation[1].
CAS Number
[2458170-54-0]
UNSPSC
12352005
Target
Apoptosis; CaMK; PROTACs
Type
Reference compound
Related Pathways
Apoptosis; Neuronal Signaling; PROTAC
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/protac-eef2k-degrader-1.html
Purity
98.64
Solubility
DMSO : 25 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
CCN1C(N(C(C2=C1N=C(C(C(N)=O)=C2)N)=O)CC(NCCOCCNC(COC3=CC=CC4=C3C(N(C4=O)C5CCC(NC5=O)=O)=O)=O)=O)=O
Molecular Formula
C31H33N9O11
Molecular Weight
707.65
References & Citations
[1]Yao Liu, et al. Designing an eEF2K-Targeting PROTAC small molecule that induces apoptosis in MDA-MB-231 cells. Eur J Med Chem. 2020 Oct 15;204:112505.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CaMK III/eEF-2K

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