PROTAC eEF2K degrader-1

• Description:

  PROTAC eEF2K degrader-1 (Compound 11l) is an eEF2K-Targeting PROTAC small molecule that induces apoptosis in MDA-MB-231 cells. PROTAC eEF2K degrader-1 mediates eEF2K degradation[1].

• UNSPSC:

  12352005

• Target:

  Apoptosis; CaMK; PROTACs

• Type:

  Reference compound

• Related Pathways:

  Apoptosis; Neuronal Signaling; PROTAC

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/protac-eef2k-degrader-1.html

• Purity:

  98.64

• Solubility:

  DMSO : 25 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles:

  CCN1C (N (C (C2=C1N=C (C (C (N) =O) =C2) N) =O) CC (NCCOCCNC (COC3=CC=CC4=C3C (N (C4=O) C5CCC (NC5=O) =O) =O) =O) =O) =O

• Molecular Formula:

  C31H33N9O11

• Molecular Weight:

  707.65

• References & Citations:

  [1]Yao Liu, et al. Designing an eEF2K-Targeting PROTAC small molecule that induces apoptosis in MDA-MB-231 cells. Eur J Med Chem. 2020 Oct 15;204:112505.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C (Powder, sealed storage, away from moisture and light)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  CaMK III/eEF-2K

• CAS Number:

  2458170-54-0