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PROTAC TEAD degrader-1

CAT: 0931-T209844-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T209844-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
PROTACs, YAP
Related Pathways
PROTAC, Stem Cells
Bioactivity
PROTACTEAD degrader-1 (Compound 27) is a PROTAC degrader of the transcriptional enhanced associate domain (TEAD) . It selectively degrades Flag TEAD2 through a ubiquitin-protease-dependent mechanism, with a DC50 of 54.1 nM in 293T cells. This compound inhibits the proliferation of NF2-deficient NCI-H226 cells, showing an IC50 of 0.21 μM, and modulates the expression of yes-associated protein (YAP) target genes.
Molecular Formula
C44H41F3N6O7
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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