BPH-715

• Description :

  BPH-715 is a bisphosphonate, inhibits Plasmodium liver-stage growth, with an IC50 of 10 μM for Plasmodium exoerythrocytic forms in HepG2 cells[1].

• Product Name Alternative :

  Tyrosine kinase-IN-1

• UNSPSC :

  12352005

• Target :

  Parasite

• Type :

  Reference compound

• Related Pathways :

  Anti-infection

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Infection

• Assay Protocol :

  https://www.medchemexpress.com/BPH-715.html

• Purity :

  99.62

• Solubility :

  0.5 M NaOH : 80 mg/mL (ultrasonic; adjust pH to 11 with NaOH) |DMSO : 5 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles :

  CCCCCCCCCCOC1=C[N+](CC(P(O)(O)=O)P(O)([O-])=O)=CC=C1

• Molecular Formula :

  C17H31NO7P2

• Molecular Weight :

  423.38

• References & Citations :

  [1]Singh AP, et al. Lipophilic bisphosphonates are potent inhibitors of Plasmodium liver-stage growth. Antimicrob Agents Chemother. 2010 Jul;54 (7) :2987-93.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  Plasmodium

• CAS Number :

  [1059677-23-4]