BPH-675

• Description:

  BPH-675 is a large bisphosphonate inhibitor with long hydrophobic side chains and a potent and selective geranylgeranyl diphosphate synthase (GGPPS) inhibitor with an IC50 of 0.71 μM. GGPPS inhibitor promotes HUVEC apoptosis[1][2].

• UNSPSC:

  12352005

• Target:

  Apoptosis

• Type:

  Reference compound

• Related Pathways:

  Apoptosis

• Field of Research:

  Others

• Assay Protocol:

  https://www.medchemexpress.com/bph-675.html

• Smiles:

  O=P(O)(C(CC1=CC=CC(C2=CC=CC(NS(=O)(C3=CC4=C(C=CC=C4)C=C3)=O)=C2)=C1)(P(O)(O)=O)O)O

• Molecular Formula:

  C24H23NO9P2S

• Molecular Weight:

  563.45

• References & Citations:

  [1]Guo RT, et al. Bisphosphonates target multiple sites in both cis- and trans-prenyltransferases. Proc Natl Acad Sci U S A. 2007 Jun 12;104 (24) :10022-7.|[2]Chong D, et al. Geranylgeranyl pyrophosphate-mediated protein geranylgeranylation regulates endothelial cell proliferation and apoptosis during vasculogenesis in mouse embryo. J Genet Genomics. 2021 Apr 20;48 (4) :300-311.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [946417-21-6]