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BPH-675

CAT: 0804-HY-136829Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-136829Size:1 Each
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
BPH-675 is a large bisphosphonate inhibitor with long hydrophobic side chains and a potent and selective geranylgeranyl diphosphate synthase (GGPPS) inhibitor with an IC50 of 0.71 μM. GGPPS inhibitor promotes HUVEC apoptosis[1][2].
CAS Number
[946417-21-6]
UNSPSC
12352005
Target
Apoptosis
Type
Reference compound
Related Pathways
Apoptosis
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/bph-675.html
Smiles
O=P(O)(C(CC1=CC=CC(C2=CC=CC(NS(=O)(C3=CC4=C(C=CC=C4)C=C3)=O)=C2)=C1)(P(O)(O)=O)O)O
Molecular Formula
C24H23NO9P2S
Molecular Weight
563.45
References & Citations
[1]Guo RT, et al. Bisphosphonates target multiple sites in both cis- and trans-prenyltransferases. Proc Natl Acad Sci U S A. 2007 Jun 12;104 (24) :10022-7.|[2]Chong D, et al. Geranylgeranyl pyrophosphate-mediated protein geranylgeranylation regulates endothelial cell proliferation and apoptosis during vasculogenesis in mouse embryo. J Genet Genomics. 2021 Apr 20;48 (4) :300-311.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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