TAK-715

CAT: 0804-HY-10456-01Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-10456-01Size:5 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

TAK-715 is an orally active and potent p38 MAPK inhibitor with IC50s of 7.1 nM, 200 nM for p38α and p38β, respectively. TAK-715 inhibits casein kinase I (CK1δ/ε) to regulate activation of Wnt/β-catenin signaling. TAK-715 shows good significant efficacy in a rat arthritis model[1][2].

CAS Number

303162-79-0

UNSPSC

12352005

Hazard Statement

H302, H319

Target

Casein Kinase; p38 MAPK; Wnt

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; MAPK/ERK Pathway; Stem Cell/Wnt

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/TAK-715.html

Purity

99.76

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C(C1=CC=CC=C1)NC2=NC=CC(C3=C(N=C(S3)CC)C4=CC=CC(C)=C4)=C2

Molecular Formula

C24H21N3OS

Molecular Weight

399.51

Precautions

H302, H319

References & Citations

[1]Saito A, Yamamoto M. Acute oral toxicity of capsaicin in mice and rats[J]. The Journal of toxicological sciences, 1996, 21 (3) : 195-200.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

Phase 2

Isoform

CK1; p38α; p38β; p38γ; p38δ

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HY-W953675	CRBN ligand-715
HY-16475-01	TAK-441
HY-122190-01	TAK-071
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466790-01	TAK 715
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