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BPH-1086

CAT: 0804-HY-147304Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-147304Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
BPH-1086 (compound 10) is an IspH inhibitor, IspH domain fused with ribosomal protein S1 (RPS1) can bind to mRNA or form part of the bacterial ribosome[1][2].
CAS Number
[1226901-43-4]
UNSPSC
12352211
Target
Bacterial
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/bph-1086.html
Solubility
10 mM in DMSO
Smiles
O=P(O)(OP(O)(O)=O)OCC#CC
Molecular Formula
C4H8O7P2
Molecular Weight
230.05
References & Citations
[1]Wang W, et al. Bioorganometallic mechanism of action, and inhibition, of IspH. Proc Natl Acad Sci U S A. 2010 Mar 9;107 (10) :4522-7. |[2]Rao G, et al. IspH-RPS1 and IspH-UbiA: "Rosetta Stone" Proteins. Chem Sci. 2015 Dec 1;6 (12) :6813-6822. |[3]Singh KS, et al. IspH inhibitors kill Gram-negative bacteria and mobilize immune clearance. Nature. 2021 Jan. 589 (7843) :597-602.|[4]Oldfield Eric, et al. Enzyme inhibiting compounds and methods: United States, US8609638 B2. 2013-12-17.|[5]Oldfield Eric, et al. Preparation of alkynyl diphosphates as Enzyme inhibiting compounds and methods: World Intellectual Property Organization, WO2011044505 A2. 2011-04-14.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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