BPH-1086

• Description:

  BPH-1086 (compound 10) is an IspH inhibitor, IspH domain fused with ribosomal protein S1 (RPS1) can bind to mRNA or form part of the bacterial ribosome[1][2].

• UNSPSC:

  12352211

• Target:

  Bacterial

• Type:

  Reference compound

• Related Pathways:

  Anti-infection

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Others

• Assay Protocol:

  https://www.medchemexpress.com/bph-1086.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=P(O)(OP(O)(O)=O)OCC#CC

• Molecular Formula:

  C4H8O7P2

• Molecular Weight:

  230.05

• References & Citations:

  [1]Wang W, et al. Bioorganometallic mechanism of action, and inhibition, of IspH. Proc Natl Acad Sci U S A. 2010 Mar 9;107 (10) :4522-7. |[2]Rao G, et al. IspH-RPS1 and IspH-UbiA: "Rosetta Stone" Proteins. Chem Sci. 2015 Dec 1;6 (12) :6813-6822. |[3]Singh KS, et al. IspH inhibitors kill Gram-negative bacteria and mobilize immune clearance. Nature. 2021 Jan. 589 (7843) :597-602.|[4]Oldfield Eric, et al. Enzyme inhibiting compounds and methods: United States, US8609638 B2. 2013-12-17.|[5]Oldfield Eric, et al. Preparation of alkynyl diphosphates as Enzyme inhibiting compounds and methods: World Intellectual Property Organization, WO2011044505 A2. 2011-04-14.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [1226901-43-4]